I dont like isolating at all.
Its better to just constantly work the whole crowd. First the entire club, then set by set, then the whole club, then go back to individual girls and start up more personal convos. Usually by this point, the girls will actually be trying to start them with you, and will be "chasing" you (girls rarely actually chase, instead they will try to hook and hold you when you cruise by). And then "isolation" will happen entirely spontaneously, and yeah, just like Rye and Chief and others say,
right next to her group of friends.
I mean, you've never had an hour long discussion with a girl at a crowded scene, without either of you saying another word to anybody else for the entire duration??
That is perfect isolation.
As far as physical isolation goes, its best not to prematurely peel them away. They will naturally follow you somewhere, you will naturally end up in a sex location, and then you are getting laid. Really its the girl making this decision, or rather, its you setting it up so that she is able to make this decision.
That, or they wont, and you are better off making her laugh in front of all her friends all night, so then she is calling you back the next day or so and setting it up so that it does happen. (Her friends will call you too =P)
You dont want her saying to all her hot gf's, "omg that guy was so nice, but then he tried to trick me over to his place and blah blah blah! All he wanted was to get in my pants! What a creep!!" You dont want her even thinking this.
As far as making out goes... DiCarlo has a point about breaking the "ramp".. there are a certain amount of girls who will flake out on you if you dont escalate it to finish.. Still, it can be nice to make out half the night as well, and there are a certain amount of girls who dont mind picking up where you last left off, either
