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Lets say I am in a setting with a group of girls, and guys, like a party for example, some of whom are known to each other and the others are not. Is it a good idea to not know who my target for the night is and try to game as many as possible simultaneously, or should I focus on that one girl ?
Depends?
If there's one in particular you want to get with because you already know her a little bit - then you'll have focus on her, obviously.
If you're just trying going in crapshoot style to get whatever you can get - then it doesn't matter which one you go after.