great question man, i love answering this one
firstly, of all i should point out you shouldnt really try and flirt with girls at work - couldnt you get in trouble?
secondly, if you break rapport with "nice nails, are they real?"
if you cant tell real nails from fake nails youll look like a fool

dont use that NEG anymore. Mystery sucks
ask her where she is from and then have a comeback for like every location
her: "i'm from Chicago"
you: "oh, so all you do is drink beer and eat pizza"
her: "i'm from Orange County"
you: "is it true about what they say about girls from Orange County?"
her: "what do they say?"
you: "their orange"
Her: "i'm from Arizona"
You: "omg you know the best think about Arizona?"
her: "what?"
you: "the Arizona tea" (btw, Arizona tea is not made in Arizona and they all know that)
thirdly, it is funny for a second and then goes cold because you have to reward her by sexually escalating (with a hug or something)
IE: haha bring it here! *HUG*
and continue the conversation.
hope this helps - keep the conversation high energy
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