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Ummm.. what okcupid are you on? Do you live in a city with 10 people? Like anything there's gonna be some attractive people and some that aren't. What kind of messages are you sending them? If it's just "hey, what's up?", then no, you're not gonna get a response. If you're not asking them questions or are curious about getting to know them (which it sounds like you aren't), then yes, they will stop responding after 2 messages. If you don't have anything interesting going on, then no, they will not respond to you.
OKCupid can vary in quality by city. My city, Buffalo, kind of sucks for it, I feel like I've messaged every attractive woman in Buffalo already. Meanwhile I'm close enough to Toronto that I keep seeing women in my searches and feeds and occasionally I'll search Toronto too. The number of attractive women is insane there, plus when I message the women from Toronto I get responses far more often. I usually don't follow up because I can't even go to Canada anyway, just pointing out that it varies.
OP check out some of the other online sites, of OKC isn't popular in your area maybe all the women are on POF. Or Match.com but I don't like using a pay site that much, and they ripped me off once by charging me after I'd cancelled.