I'm losing all relationships.

My sister dosent communicate with me anymore. It was always a sorta bad Relationship but it was coming better then I sent her a Facebook message with a Harry potter joke in it. She laugh hard in a few seconds and replyed, then I sent her ''thx for the message u left on my desk, made my heart warm'' and then she took 20 minutes to answer and said ''it was just a small message ^^'' and when i saw her back she didnt say hello and didnt want anything from me. I think she thinks I want to buy or manipulate her love or some shit.

My uncle dodge any attempt to go play guitar with him and call excuses and dosent call me back if I leave a message on his answering machine.

My best friend that was my therapist a few years ago does not call me back when I leave a message on her answering machine.

My online friends stop messaging me, breaks communications and find excuses to stop everything else that includes me.

Not even talk about more or less random girls that never calls me or initiate anything.

I'm about to go live in a fucking cave and find something that does not include anybody in this fucking cold world. WTF is happening, WTF am I doing wrong? (you can ask me questions about me if u think you are able to put the finger in it with a few more informations) WTF can I do to be happy without anybody? WTF to get the Relationship I want with the people I want?

This is inexplicable without more information. Only you can know. My best guesses are:

You did something unethical that everyone knows about.

or

You have changed so much due to Pick Up that people are not sure what to think of you.