When you are past the beginner issues like AA, confidence, body language etc (stuff that most forum posts here is about), pickup and seduction ultimately boils down to a few simple things:
1. Offer value. This by far the most important thing, and probably your core issue, but it is quite vague. It means that you need to entertain your audience, make them happy and feel good around you. You don't have to be a standup comedian, but you need to be stimulating, interesting, and/or the one who amps up the energy. Many guys need to be
in state in order to do so (like me). I can see the difference like day and night when I'm
in state compared to
out of state. It is of course
possible to attract someone talking about computers, if you can find a girl who is interested in the same areas as you, but it is definitely not as easy. Psychology wins over computer science here. Easy.
2. Keep her attention on you at all times. Constant attention is key to seduction.
3. Be dominant and all that stuff.
So the short answer is: Yes, everything is possible. You just make it harder for yourself.