I find that it's easy for me to open a set, and get them talking. However I've noticed that there have been a few times where I've been running a set real well and getting IOI's, and I don't know how to isolate the target, so I end up just walking away and saying "See you guys later. I've got to get back to my buddies." I try and convince myself I'm just using a takeaway to keep them chasing me, but in reality, I know it's because I don't know where to go from there.

So what are you guys' best techniques to isolate a target?

Hey man, isolating the target isn't as much about techniques as about increasing the levels of comfort and confidence in your target. If you get her invested in you to the point of isolating her, you can always ask her to walk with you to the bar to get some drinks, to sit down on a couch in a quieter place in the club, to step outside for a cigarette, any pretext will do... Just make sure you have passed the "funny guy I just met" status in her eyes and gone to the "guy I just met that I have a great connection with" level... Isolation is more about the right timing... You can say just "Let's go over there" and she'll follow if you have established that connection...

Exactly. just "TELL" her what you want to do with her, and LEAD. She will follow you and expect her to follow you.

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How to Get an Awesome Girlfriend
How to Train your Girlfriend