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In my opinion the more you know about the scientific aspect the better suited you will be to interpreting your target and reading between the lines.
You may be better at analyzing the situation afterwards. In the moment when you are actually in the situation with the 'girl', it's different. If you've neglected to actually apply(put into practice) the scientific information you've learnt, it's really hard for it to help.
Lets say you ARE consciously thinking of what you need to do over the top of all the other noise a newbie might have in his head whilst talking to the girl. It's probably not going to help to start off with, the information's not apart of who he is yet.
The information can be the seed, and it's useless unless you're putting effort in to making it grow(i.e; the social interactions you have). Tyler durden says a similar idea to this in the blu print.
I agree with you in the fact that scientific aspects are good, and takes you beyond a level of just 'natural'. However only once you've fertilized that seed(idea) with experience. Until then it's just a useless seed that can't do shit.