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If you're young and have energy, try the pub crawl.
there are several i think one goes of out Liedseplein or whatever its called.
When i was 20 years old i did it with my bro a few times, had a great time
going from party to party.
you meet tons of people on the way, drink alot and usually end up hooking up unless you're too wasted to make sense.
also in Alexanderplatz there are a few places, and there's a club called
"The Matrix" which is cool.
Leidseplein is in Amsterdam... Alexanderplatz used to be big but when I was there everything was closed and boring. The Matrix was nice just make sure you go on the weekend, during the week Berlin is pretty damn dry.
I didn't go on the pub crawl but I did go there when I was in Amsterdam and it was fucking great. If it's the same thing in Berlin then definitely go there, you drink a lot and make friends with your group.