Hah, i'va played around with this opener quite a lot. "Do i look gay, because some dude randomly hit on me or someone said something weird" or something. I haven't made it all about one specific item, but usually just "ah it's about my suit". Works well

The point is to escalate. And it's easy enough if you are fashionable, just push some related topic and move on.
Now, for the "yes" part. You can push it a bit farther, make a girl emphasize it, and then "ah, i've heard girls have no problems with kissing gay guys, so prove it". Or play an insecure guy who takes it personally. As far as i'm concerned and as far as i've used this opener, the point is to make the object of your game DHV to you. You just sit back and let her make the magic happen.