Okay so you've opened a two set blablabla and you're getting IOIs from the target.

What are some ideas of how to isolate in this situation since she will not want to leave her friend (let's say they are both girls).

You have no wingman!

I've had no good ideas on this so far so all ideas are appreciated!

Wait until the target is touching you a good amount, or gives major IOI's, it's pretty easy usually to tell if she wants to be isolated. In fact, if you're doing well enough, her friend may just leave you two alone.

Charm them both the whole night, but make it obvious who you're there for. When your obstacle goes to the bathroom, be aggressive with your target. If girls go out in pairs, it's really unlikely her friend is going to ditch her or ignore her so some random guy can feel her up in the corner. Live it up, you're such a man, two girls are paying attention to you, everyone will think it's Three's Company.

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31 and still figuring it out.

Not bad advice. I have tried this in field and found that when you do this you can hit the LJBF zone very hard. When you make it obvious who you're therefore while impressing both of them the obstacle will actually drag you that place. Saying things like

"Oh wow you're so kool you're gonna be our new best friend !!"
I usually reply with "No I'm no ones best friend"

I think they do this out of jealously. You've probably seen guys miss out on a kiss close because some jealous girl comes out of nowhere and drags her friend off. I think it's a more subtle version of that.
Not bad advice actually. Minsok has a point. Getting a girl so interested and excited that her friend will leave you alone would take incredible game however and not to mention luck.

So is there no actual method for isolating in a two set?

Yeah, there's a huge possibility of Friend Zone. I was in this exact situation last week, but I didn't make it OBVIOUS which girl I wanted, so not surprisingly I got two friends. No big deal. If I was to do it again, with a goal in mind, I would have ramped up the kino on the target, verging on boyfriend behavior. At the end of the night, I would have asked the odd girl out to give me a minute alone (in a very friendly way) with her friend and pushed for a day 2 if not a quick kiss close. You can probably only get a few minutes without having the target feel guilty about ditching her friend.

Ideally, you'd call up a friend that lives nearby to entertain your obstacle. You could maybe offer to introduce her to a guy she likes in the place, but that could get awkward if he's not interested.

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31 and still figuring it out.

This may seem weird. But if I've made two 'friends' and then I try catch a moment alone with one to get a day 2 or watever I feel guilty. Because I feel like the other friend will feel used and like i tricked her to get to her friend?
Not trying to be over to top and not sure if you can feel where I'm coming from. But that feeling she would get where you're like can I be alone with your friend, then you ask her on a date or something. The other girl would feel used. I think you're gonna say,
"who cares about her?"
and tell me I shouldn't. You're probably right sometimes you have to be mean in the game. But from game perspective the feelings that friend would get from that might hurt my day 2? Not sure if you can feel where I'm coming from, if not no problem.

I guess I could see that. But that's why it's important to be obvious who you're going for at all times, unlike what MM might say. Otherwise the friend might feel like you rejected her, too. Your thinking is kind of screwed up, but it's possible that a girl might agree with you, I dunno. Basically, you're an outsider, you came into this tiny social circle and you made their night more interesting. You provided value. I don't know why you'd feel like you manipulated or used one of the girls. You were just entertaining yourself and them and it just so happened that you were attracted to one girl more than the other, it would only be a problem if you built so much attraction with the friend that your target would feel guilty hooking up with you (another reason to focus on target).

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31 and still figuring it out.

Haha minsok! The weekend after your post this happened. At the time I was actually thinking about what you said about not feeling bad for the obstacle etc.
Actually picked up the 2 hottest babes in a club on the weekend. One was a 10 and one was a 9. I had them on the couch i was sitting in the middle running game and had about 5 AFCs looking on and I could read their minds, "how the fuck is he with them?". Don't ya love the game?

Anyway, I'd love to stop bragging but something even more amazing happened. The two girls started to fight over me. One turned to me and even said "you're making us do this" I just told them I wanted everyone to be friends.

So a little later I isolated the 10 she said 2 things
1) I thought you were gay
and
2) oh i thought u liked my friend

I passed the shit tests and we hooked up

The friend was PISSED tho
she left the club and me and HB10 followed back to their hotel room
both of them nearly punched on.
We get back to the hotel room HB 9 is being a big sook then says shes gona leave us alone. HB 10s mood is pretty shit right now because her friend is being a sooky bitch, which ultimately meant we just fell asleep with no action.

That's the feeling I was talking about. In a two set you engage both members fully and both hear your DHVs etc. So both may be attracted to you. That 'bad feeling' I mentioned is the one where the obstacle might become an emotional problem for your friend because she likes you too. I mean you want attention from the obstacle to help you win your target. But how do you

Balance attention from your obstacle to win attention from the target

while

Push pulling the target

while

ultimately picking up the target without her thinking you like her friend at all?? So she doesn't feel bad or guilty or worse punching on with her friend?

CAN ANYONE HELP????
I feel this is deep sorta stuff but really need to get peace about it nonetheless as it's affected my game AGAIN :(

Damn, and you were doing so well. Sucks that her friend cock blocked you like that, I guess that happens with younger girls.

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31 and still figuring it out.

hmm yea i guess if anyone figures out how to dhv and only pick up the target plz share

Don't kino the obstacle

To b H
I think this is one of the best answers.
I didn't kino her much at all, but I can see now how even the smallest amount of kino in this situation can lead to you getting shot down later. I suppose you wanna give her as little ammunition as possible so when you try isolate the target the obstacle can convince herself that there was nothing between you.