I haven't completely alienated anyone since beginning my transformation, but I have definitely grown apart from people, especially a few girls (platonic "best friends") who had me hopelessly friend zoned and constantly bedeviled me for the longest time.
Those "old friends" were exposed to me as a very passive, anxious, obnoxiously agreeable person (the kind of person who would go with them to, say, shoe stores and midnight showings of "Twilight" just to hang with them instead of manning up and saying that I would rather eat glass).
Since I strongly believe that we develop friendships with people who have qualities we want in our lives, I can only conclude that they wanted a guy friend who was non-threatening, easily persuaded, etc, and I fit the bill perfectly.
Then...
I got over some personal issues, which I discussed in another thread, and started studying and applying game to my life.
I would be out with these girl friends and start gleefully flirting with and number closing women in restaurants, movie theaters, malls, and anywhere else. They would look at me like one might look at a guy running naked through a graveyard.
I would tell them of my successes with women, and they would get hilariously uncomfortable, obviously forgetting all the times I listened to them talk about the latest winners they were dating.
The point is that I was a different person to them, and so they had to evaluate whether this new person had traits that they wanted in their lives, just as they had done upon meeting me for the first time. Two of them, I guess, decided that I was no longer appealing as a close friend. Though, because I was more self-assured, I was totally okay with that. The other is still a dear friend and a world-class pivot.
Meanwhile, new friends I make are befriending someone who is a (more) confident, assertive, and socially aggressive person, and the friendships are a million times healthier for it.