What's a good way to respond to this shit test:
"Leave her alone, she's not going to sleep with you!"

I've only gotten it in a joking manner from my female friends, but I'm sure it will come up in the future from a girl with a particular strong bitch shield.

I remember Style saying "Woah, hang on. I need trust, comfort, and a connection first," but I don't recall it working all that well for him in The Game. Plus that's not a great way to respond if it's said in a joking manner.

Just laughing is always a good go-to, but since I generally AM trying to sleep with the girl, I can't laugh as genuinely as I would like to. I saw one of my natural buddies get hit by this test the other day and it completely ruined him. The girl got uncomfortable and walked away and the obstacle just gloated for knocking him down a peg.

I was thinking it could be used as an opportunity to neg that target- "Ew! She's JUST like my little sister!" but if I've already reached A3 then I wouldn't want to be negging anymore.

So far the best thing I've come up with is to tease the obstacle. "But (obstacle), -you're- the one I'm crazy about! Haven't you gotten all those letters I sent you?" Takes a shot at her confidence by displaying that you aren't interested in her and completely ignores the target.

Any other responses would be appreciated.

Personally I LOVE calling the girls out on things like this.

If the obstacle says, "Leave her alone, she's not going to sleep with you!" I personally like responding with something along the lines of, "Wow, you have a one track mind don't you? Don't worry, not every guy is as sex focused as you seem to be." Then go to the target and say "I hope you're not as perverted as your friend over here."

Pros:
You are no longer seen as "that horny guy"
You engaged the obstacle first and caused the target to need to qualify herself to you in her response.

Cons:
You have essentially made it so that the target does not equate you with sexual activity

I feel that if you want to, you can negate this con by using stealth seduction techniques after isolation, so it's not as bad of a con as it would first seen. This is, however, assuming that this shit test is given by the obstacle relatively early on.

I warn you though, I have NOT field tested this specific one yet, so the results are kinda up in the air. The general formula of negging the obstacle and causing the target to try to qualify IS field tested though, so I'm using an "a = b = c" reasoning when I suggest this approach.

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I don't like taking the easy way out. I'd rather be creative.

She is just challenging you.

Sample response: "Of course she won't - I'm not sure if she can handle me." - it challenges the girl. Then you can say to her: "Why is this girl always talking to me about sex?"

The key here is to find a response that you feel 100% confident when saying. Otherwise you won't get much even with the perfect line.