There have been a couple times when I am gaming a girl and i struggle with when to switch from the neg to comfort to direct. What are some IOI's that i can look for which indicate time to switch the frame to increase my game efficiency?

Please forget about that, forget about negging and all that, just focus on getting into the right mental state that's all you have to "worry" about, once you are there you don't have to worry about negging or going direct or indirect. Use the type of game that goes with your personality if you are shy don't use direct; use things or say things that you find comfortable saying.
Don't neg because you read in a book that you have to do it, trust me you don't,
One of the differences between the guys who are very good at this and the guys who are just ok is about THE ABILITY TO ADAPT TO DIFFERENT SITUATIONS.

You can also check this video, here I talk about the different mental states.
http://www.youtube.com/watch?v=V-WCQTlH ... AAAAAAACAA


Good luck.

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Winners have simply formed the habit of doing things losers do not like to do 18/03/12

thank you for the video, i apologize for the late response i've been otherwise occupied with school since its started. Could we exchange emails? I would like to learn more.